Agenda IB

Renato Vicentini dos Santos
Several molecular mechanisms responsible for the cross talk between different regulatory elements and signaling pathways, and their diversification in plants, still need to be elucidated to better understand plant growth patterns and biomass production. Our laboratory applies genetic and computational approaches to integrate molecular and systems biology to improve the knowledge about several biological mechanisms in plants. Recently we are elaborating ways to analyze regulatory network and dynamic metabolic models in sugarcane related with sucrose biosynthesis, and define the diversification of different signals programs among angiosperms.

Danilo Ciccone Miguel
My main interest in basic research is focused on understanding the mechanisms that allow Leishmania to survive in the intracellular environment. In our Lab, we also study the efficacy of several compounds aiming at the discovery of novel/repurposed drugs for leishmaniasis treatment.
https://www.unicamp.br/unicamp/ju/noticias/2021/06/16/qual-e-o-impacto-…

Helena Coutinho Franco de Oliveira
We have focused on the role of plasma lipoprotein metabolism and associated proteins particularly relevant for the development of atherosclerosis, diabetes and obesity. Hormonal, nutritional and pharmacological regulation of key proteins involved in the metabolism of plasma lipoproteins are investigated with the goal of elucidating molecular mechanisms and putative therapeutic targets for cardio-metabolic disturbances. Scientific contributions have been made concerning the understanding of CETP (cholesteryl ester transfer protein) gene expression and its effects regarding atherosclerosis susceptibility and possible new functions of this protein (Oliveira HCF, Raposo HF. Adv Exp Med Biol. 2020). Together with Anibal Vercesi group, we have demonstrated that mitochondrial bioenergetic function and redox state alterations are present in hyperlipidemic states that predispose to atherosclerosis (Oliveira HCF, Vercesi AE.Mol Aspects Med. 2020)