The main purpose of our laboratory activities is to investigate the mechanisms involved in endothelial dysfunction in cardiovascular disease and how these are influenced by chronic aerobic exercise training. In this context, we are particularly interested in vascular nitric oxide bioavailability, oxidative stress, inflammation and the perivascular adipose tissue.
Prof. Dr. Fabio Papes\\\\\\\' laboratory has two main lines of investigation:
(a) Molecular Studies of the Olfactory System:
In this project, the laboratory intends to understand the molecular bases of the most primitive sensory system found in animals, the Olfactory System, using mice as model animals and Molecular Biology tools. Through genetic manipulation experiments (animal transgenics, optogenetics, chemogenetics and neuronal tracing), the laboratory seeks to understand how odors are detected by the two olfactory sensory organs (main olfactory epithelium and vomeronasal organ), how olfactory information is transferred to the olfactory regions in the brain, and how behavioral responses are generated toward chemical stimuli. In particular, the group studies maternal and paternal behavior, in addition to defensive and sexual behavior. The team has published numerous scientific articles in high-impact journals and has several research collaborations with institutions in Brazil and abroad.
(b) Neurobiological studies of neurological and neuropsychiatric disorders:
Prof. Fabio Papes studies autistic spectrum disorders, seeking to understand their underlying pathophysiology, genetic bases and molecular mechanisms, with the goal of developing pharmacological and genetic therapeutic strategies. Through the use of in vitro cellular models, particularly those derived from patients, the group employs Molecular Biology tools to study autism and its cellular processes.
Prof. Fabio Papes is one of the PIs at the Laboratory of Genomics and Bioenergy (LGE) and at the Center for Medicinal Chemistry (CQMED) at UNICAMP.
Biology, ecology and taxonomy of Diptera and Coleoptera of forensic importance. Larval therapy. Insect vectors and pests.