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Agenda IB
Carla Beatriz Collares Buzato
Our research group focuses on the study of cell-cell and cell-matrix interactions mediated by cell junctions and their role in tissue homeostasis, particularly of epithelial tissue. The current lines of research are: 1) to understand the mechanisms of regulation of intercellular junctions in vivo and in vitro models, 2) to investigate the importance of cell-cell contact mediated by intercellular junctions in the process of cell maturation and dysfunction pancreatic beta during development and in the context of type 2 diabetes mellitus (T2D), and 3) to study the role of the intestinal epithelial barrier mediated by the occlusion junction in the pathogenesis of T2D and its regulation by the microbiota and by short-chain fatty acids. We use in the laboratory a multidisciplinary approach that integrates tissue and functional biology, confocal laser scanning microscopy, electrophysiology, physiology of intercellular/transepithelial transport, and molecular biology (Western Blot and Real-Time PCR) to define fundamentals of the structure and function of cell junctions and understand the regulatory mechanisms of these structures in vivo and in vitro models. This research can contribute to our understanding of the pathophysiological function of junctions and support research aimed at determining ways and pathways for regulating these membrane specializations with possible application in the treatment of certain diseases associated with their dysfunction. (CNPq Group, Communication and Cellular Adhesion).
Fabio Pinheiro
My research is focused to understand the evolution of reproductive barriers among lineages and populations, which is a key step in speciation. A diverse array of mechanisms, such as hybridization, introgression and selection for divergent habitats are investigated in order to understand plant speciation within Neotropical region. Our lab members use different but complementary approaches to understand the first steps of speciation. Students from different research fields are welcome.
