The Laboratory of Reproductive Biology has studied the prostatic microenvironmental changes such as proliferative lesions associated or not with the aging process. The prostatic stroma dynamics as well as the stroma-epithelium interaction have also been the focus of our research, due to the main roles of these glandular compartments in the development and progression of the prostatic lesions associated with inflammation; angiogenesis; and oxidative stress. These studies have used different therapies, including those with natural compounds such as Brazilian berries, and a transgenic adenocarcinoma of the mouse prostate (Tramp) model. In addition to this, biological techniques for instance, immunohistochemistry; western blotting; microdissection; morphology; stereology and PCR have been used. Others studies using human prostatic cells (in vitro) focusing on prostatic cancer; hormonal imbalance; and biological processes (angiogenesis; inflammation; and oxidative stress) have also been developed.
Screening for molecules controlling essential biological processes in insects through gene silencing (RNAi), genomic editing (CRISPR-Cas9) and global gene expression analysis (RNA-seq) techniques aiming at the development of sustainable biotechnological solutions to control agricultural pests.