Research areas

Research lines

 

1. Acid phosphatases and protein tyrosine phosphatases as markers of cytotoxicity, environmental pollution, germination and expression;

2. Actions of nitric oxide and its derivatives on plant and animal metabolism;

3. Applied enzymology of phosphatases and kinases; in vitro bioassays and signal transduction in tumor cells;

4. Association among nutrition, cancer and pregnancy. Metabolic and molecular processes of cachexia;

5. Bacterial pathogenicity and genomics and expression of antigens in bacteria;

6. Bioenergetics and antioxidant mechanisms in Trypanosoma cruzi;

7. Biomembranes and biomimetic processes, interaction of local anesthetics with model membranes, and of amphiphilic membranes with natural membranes;

8. Cancer immunology, immunoengineering, viral immunology, virology applied to gene therapy and immunomodulation;

9. Cardiovascular, metabolic and behavioral responses to steroid hormones;

10. Characterization of animal toxins, and protease and lectin inhibitors;

11. Characterization of microbial toxins;

12. Cytotoxicity, mechanisms of apoptosis induction and antitumor effects of biopharmaceuticals and nanoparticulate compounds on different cell models;

13. Effect of melatonin and dietary fiber on cardiovascular and metabolic parameters;

14. Exercise Biochemistry;

15. Functional and molecular mechanisms involved in the vascular alterations resulting from disorders of the cardiovascular system with emphasis on the role of the endothelium;

16. Genetic improvement and citrus biotechnology. Functional genome of Xylella fastidiosa, Xanthomonas axonopodis pv citr, citrus leprosis virus, citrus tristeza virus;

17. Haemostasis and Thrombogenesis;

18. Human parasitic diseases (Leishmaniasis and Chagas disease), intracellular traffic mediated by myosins and enzymes with biotechnological and biomedical applications;

19. Insulin secretion in malnutrition and obesity;

20. Mechanisms of cell signaling in cardiomyocytes, pathogenesis and pathophysiology of hypertrophy and heart failure, and drug discovery and development;

21. Metabolic and cardiovascular changes in morbidly obese animal and human models;

22. Microbial Biotechnology;

23. Models of cooperativity and allosteric regulation and dissociation of proteins by high hydrostatic pressure;

24. Molecular mechanisms involved in energy balance control;

25. Molecular mechanisms of pain and inflammation, sexual dimorphism in pain, inflammation and in the action of analgesic and anti-inflammatory drugs;

26. Molecular pathology of tumors of the central nervous system;

27. Nanobiotechnology, release systems for bioactive compounds such as: cyclodextrins, polymer micro- and nanoparticles, drugs and pesticides;

28. Neurobiology of pain and inflammation;

29. Nitric oxide and cardiovascular dysfunctions;

30. Ohm and HTS strategies for prospecting on enzymes of microorganisms and communities (genetic material). Development of studies aiming to correlate the structure and function of enzymes and improve the expression of recombinant proteins in filamentous fungi;

31. Pharmacological and cytotoxic study of plant lectins and plant defense mechanism;

32. Physiological and molecular bases of lipid metabolism;

33. Physiological, biophysical and molecular bases of insulin secretion;

34. Protein stability and folding pathway;

35. Proteome

36. Proteomics and mass spectrometry applied to the study of regulation and search for ADAM targets (metalloproteinases) in oral cancer;

37. Regulation of gene expression, genomes and DNA chips; Bioinformatics for genome;

38. Structural biology and metabolomics;

39. Teaching Biochemistry and Bioinformatics;